Megagrant research during the visit of the leading scientist

March 1-21, 2021, Prof. Andrey Abramov (leading scientist from UCL Queen Square Institute of Neurology, UK) was working in the laboratory. During this period, the laboratory staff conducted a series of experiments under his supervision to complete a number of project tasks of the Federal Government megagrant aimed at the implementation of the project "Mitochondria as a Target in the Mechanism of Neurodegenerative Diseases".

The laboratory staff performed their research on state-of-the-art equipment, including one of the most powerful confocal microscopes in Russia, the Carl Zeiss LSM 900 Airyscan 2 (Germany).

The results were discussed at weekly seminars in the new conference hall named after Dr. V.I. Turbin.

The video obtained by a leading researcher, PhD Alexey V. Berezhnov shows the result of an experiment to find new ways to protect cells in neurodegenerative disorders, in particular, in Parkinson's disease (PD). In the confocal image of the fibroblast of a patient with inherited Parkinson's disease (PINK1 gene mutation), the mitochondria are colored red with a potential-sensitive dye, and the cell nucleus is blue. The cells were treated with the activator of natural antioxidant defense systems RTA-408. It was observed that the cell has a normal morphology of the mitochondrial network typical in fibroblasts of healthy people, as well as the absence of pathological forms of mitochondria (the so-called mitochondrial "donuts"), which are characteristic of the cells in inherited PD. Thus, our preliminary data on cell cultures show that antioxidant therapy can be an effective means of restoring the morphology of the mitochondrial reticulum in PD.

March 10, 2021, Sc.D., PhD, head of the laboratory, Andrey Abramov, gave a lecture "Role of Nrf2 in control of bioenergetics and redox state" for the project staff, as well as students and teachers of the Institute of Natural Sciences and Biotechnology.

The report by Elena Litinskaya on the current results of the laboratory's work was broadcasted by Orel State Television and Radio Broadcasting Company (March 16, 2021).